维莫德吉
平滑
刺猬信号通路
生物
刺猬
基底细胞癌
癌症研究
内科学
药理学
细胞生物学
信号转导
基底细胞
医学
作者
Aleksandar Sekulić,Daniel D. Von Hoff
出处
期刊：Cell
[Elsevier]
日期：2016-02-01
卷期号：164 (5): 831-831
被引量：65
标识
DOI：10.1016/j.cell.2016.02.021
摘要
The hedgehog (Hh) signaling pathway is aberrantly activated in a majority of basal cell carcinomas (BCC). Vismodegib and sonidegib are targeted inhibitors of Smoothened (SMO). Both drugs are approved for use in locally advanced BCC (laBCC), with vismodegib also approved for metastatic BCC (mBCC).
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