Endothelial adherens junctions at a glance

细胞结 紧密连接 VE钙粘蛋白 细胞骨架 细胞粘附分子
作者
Elisabetta Dejana,Fabrizio Orsenigo
出处
期刊:Journal of Cell Science [The Company of Biologists]
被引量:145
标识
DOI:10.1242/jcs.124529
摘要

Adherens junctions have an important role in the control of vascular permeability. These structures are located at cell-to-cell contacts, mediate cell adhesion and transfer intracellular signals. Adhesion is mediated by cadherins, which interact homophilically in trans and form lateral interactions in cis. VE-cadherin (also known as CDH5 and CD144) is the major component of endothelial adherens junctions and is specific to endothelial cells. Endothelial cells from different types of vessels, such as lymphatic vessels, arteries and veins, show differences in junction composition and organization. Vascular permeability is increased by modifications in the expression and function of adherens junction components. In some cases these defects might be cause of pathology. In this Cell Science at a Glance article, we present the example of the so-called cerebral cavernous malformation (CCM), where adherens junctions are dismantled in the vessels contributing to brain microcirculation. This causes the loss of endothelial cell apical-basal polarity and the formation of cavernomas, which are fragile and hemorrhagic. Other diseases are accompanied by persistent alterations of vascular morphology and permeability, such as seen in tumors. It will be important to achieve a better understanding of the relationship between vascular fragility, malformations and junctional integrity in order to develop more effective therapies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
谨慎忆安完成签到,获得积分10
2秒前
忧伤的慕梅完成签到,获得积分10
2秒前
3秒前
wwqc发布了新的文献求助10
5秒前
shisong完成签到,获得积分10
6秒前
7秒前
阔达磬发布了新的文献求助10
7秒前
不配.应助冷淡芝麻采纳,获得20
8秒前
10秒前
adam完成签到,获得积分10
12秒前
12秒前
D33sama完成签到,获得积分10
12秒前
田様应助xiaolu采纳,获得10
13秒前
小马甲应助科研通管家采纳,获得10
13秒前
gnr2000应助科研通管家采纳,获得10
13秒前
hl应助科研通管家采纳,获得20
13秒前
上官若男应助科研通管家采纳,获得30
13秒前
iNk应助科研通管家采纳,获得20
13秒前
13秒前
alan发布了新的文献求助10
14秒前
许若南完成签到,获得积分10
14秒前
家家发布了新的文献求助10
16秒前
周舟发布了新的文献求助10
18秒前
20秒前
20秒前
alan完成签到,获得积分20
21秒前
辛谷方松永旭完成签到 ,获得积分10
21秒前
Chen完成签到,获得积分10
23秒前
WDS发布了新的文献求助10
24秒前
xiaolu发布了新的文献求助10
26秒前
慕燕琼完成签到,获得积分10
26秒前
26秒前
小康学弟完成签到 ,获得积分10
26秒前
小二郎应助周舟采纳,获得10
30秒前
偏i意气用事完成签到,获得积分10
30秒前
科研張完成签到,获得积分10
31秒前
Lucas应助zzk采纳,获得10
33秒前
yyxmh羽儿完成签到,获得积分10
37秒前
Jasper应助Guke采纳,获得10
37秒前
高分求助中
Evolution 3rd edition 1500
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
Ribozymes and aptamers in the RNA world, and in synthetic biology 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3180839
求助须知:如何正确求助?哪些是违规求助? 2831074
关于积分的说明 7982863
捐赠科研通 2492963
什么是DOI,文献DOI怎么找? 1329932
科研通“疑难数据库(出版商)”最低求助积分说明 635850
版权声明 602954