神经科学
海马体
痴呆
海马结构
疾病
病态的
记忆障碍
颞叶
心理学
神经影像学
医学
认知
病理
癫痫
作者
Kuven Moodley,Diane Chan
出处
期刊:Frontiers of neurology and neuroscience
日期:2014-01-01
卷期号:: 95-108
被引量:100
摘要
AD is the commonest neurodegenerative disorder resulting ultimately in dementia, a stage during which there is a loss of previously acquired intellectual skill and independent occupational and social function. Neurodegenerative changes within the hippocampus and an extended neuronal network involving the medial temporal and medial parietal lobe result in the archetypal memory impairment seen in Alzheimer's disease (AD). As attention focuses increasingly on early diagnosis and treatment of dementia, this understanding of the hippocampal involvement in AD has helped to develop diagnostic tools for use in early disease. However, hippocampal damage is also a common feature among non-AD neurodegenerative dementias. Neuroimaging techniques, in conjunction with behavioral and pathological techniques, can be used to determine the involvement of the hippocampus in AD and other neurodegenerative diseases.
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