Organocatalytic Asymmetric Hetero-Diels-Alder Reaction of Oxindoles under High Pressure¹

A general and efficient protocol for the high-pressure-promoted asymmetric hetero-Diels-Alder reactions of oxindoles has been developed. These reactions can be realized by using chiral thiourea-derived organocatalysts, and the desired adducts are obtained in good to high yields with good to moderate enantioselectivity.