Metabolites of Penicillium sp. F00120 from a Deep Sea Sediment Sample

To study the chemical constituents of deep-sea fungus Penicillium sp. F00120,nine compounds were isolated from its Et OAc extract using silica gel,Sephadex LH-20,ODS and HPLC methods. Based on the spectroscopic analysis,their structures were identified as ergosterol(1),4-methyl-5,6-dihydro-2-pyranone(2),citreohybridonol(3),1-Linoleoylglycerol(4),5α,6α-Epoxy-(22 E,24R)-ergosta-8(14),22-diene-3β,7β-diol(5),macrophorin(6),purpurogemutantin(7),3-(2S,4S-dihydroxypentyl)-6,8-dihydroxyisocoumarin(8),5-hydroxy-7-(2’-hydroxypropyl)-2-methylchromone(9). Compounds 2-4,6-9 were isolated from Penicillium sp. F00120 for the first time.