医学
质子泵
胃酸
质子抑制剂泵
内科学
应激性溃疡
低镁血症
消化性溃疡
胃肠病学
肾脏疾病
重症监护医学
疾病
消化性
上消化道出血
胃
胃肠道出血
内窥镜检查
镁
生物化学
酶
ATP酶
材料科学
冶金
化学
作者
Karen Clarke,Nicole Adler,Deepak Agrawal,Dimpal Bhakta,Suchita Shah Sata,Sarguni Singh,Arjun Gupta,Amit Pahwa,Emily Pherson,Alexander Sun,Frank Volpicelli,Hyung J. Cho
标识
DOI:10.1016/j.amjmed.2021.09.010
摘要
Proton pump inhibitors are widely used throughout the world for the treatment of gastrointestinal disorders that are related to acid secretion, such as peptic ulcer disease and dyspepsia. Another common indication for proton pump inhibitors is stress ulcer prophylaxis. Proton pump inhibitors have proven efficacy for the treatment of acid-related gastrointestinal disorders, but there is concern that their use may be associated with the development of significant complications, such as fractures, Clostridium difficile infection, acute kidney injury, chronic kidney disease, and hypomagnesemia. Proton pump inhibitors are overused in the hospital setting, both for stress ulcer prophylaxis and gastrointestinal bleeding, and then they are often inappropriately continued after discharge from the hospital. This narrative review article outlines the evidence surrounding appropriate proton pump inhibitor use for stress ulcer prophylaxis and peptic ulcer bleeding.
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