Copper‐Catalyzed Oxidative C−C Cleavage of Carbohydrates: An Efficient Access to Quinazolinone Scaffolds

Abstract A copper‐catalyzed oxidative coupling strategy has been developed for the synthesis of 4(3 H )‐quinazolinones and benzoimidazoquinazoline using glucose as renewable C 1 synthon. Isotope labelling studies using 13 C 6 D ‐glucose and DMSO‐ d 6 confirmed the role of D ‐glucose as C 1 source. The significant features of this method include (i) utilization of 0.25 to 0.5 equiv., of D ‐glucose as a multi‐C 1 synthon; (ii) biomass‐derived platform chemical as carbon synthon; (iii) atom‐economical and benign conditions and; (iv) synthesis of naturally occurring alkaloid and precursor.