神经退行性变
调节器
神经科学
疾病
炎症
发病机制
神经元
细胞因子
功能(生物学)
神经炎症
神经系统
医学
生物
免疫学
细胞生物学
基因
病理
生物化学
作者
Kai K. Kummer,Maximilian Zeidler,Theodora Kalpachidou,Michaela Kress
出处
期刊:Cytokine
[Elsevier]
日期:2021-08-01
卷期号:144: 155582-155582
被引量:82
标识
DOI:10.1016/j.cyto.2021.155582
摘要
The pleiotropic cytokine interleukin-6 (IL-6) is emerging as a molecule with both beneficial and destructive potentials. It can exert opposing actions triggering either neuron survival after injury or causing neurodegeneration and cell death in neurodegenerative or neuropathic disorders. Importantly, neurons respond differently to IL-6 and this critically depends on their environment and whether they are located in the peripheral or the central nervous system. In addition to its hub regulator role in inflammation, IL-6 is recently emerging as an important regulator of neuron function in health and disease, offering exciting possibilities for more mechanistic insight into the pathogenesis of mental, neurodegenerative and pain disorders and for developing novel therapies for diseases with neuroimmune and neurogenic pathogenic components.
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