骨化三醇受体
维生素D与神经学
急性肾损伤
医学
临床实习
维生素
维生素D缺乏
重症监护医学
生物信息学
内科学
生物
物理疗法
作者
Siqing Jiang,Lihua Huang,Wei Zhang,Hao Zhang
标识
DOI:10.2174/0929867327666201118155625
摘要
Despite many strategies and parameters used in clinical practice, the incidence and mortality of acute kidney injury (AKI) are still high with poor prognosis. With the development of molecular biology, the role of vitamin D and vitamin D receptor (VDR) in AKI is drawing increasing attention. Accumulated researches have suggested that Vitamin D deficiency is a risk factor of both clinical and experimental AKI, and vitamin D/VDR could be a promising therapeutic target against AKI. However, more qualitative clinical researches are needed to provide stronger evidence for the clinical application of vitamin D and VDR agonists in the future. Issues like the route and dosage of administration also await more attention. The present review aims to summarize the current works on the role of vitamin D/VDR in AKI and provides some new insight on its therapeutic potential.
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