软骨
组织工程
体外
II型胶原
体内
生物合成
细胞生物学
化学
生物化学
生物
生物医学工程
解剖
工程类
生物技术
酶
作者
Zhuning Wu,SH Korntner,AM Mullen,Dimitrios I. Zeugolis
标识
DOI:10.1016/j.bbiosy.2021.100030
摘要
Collagen type II is the major constituent of cartilage tissue. Yet, cartilage engineering approaches are primarily based on collagen type I devices that are associated with suboptimal functional therapeutic outcomes. Herein, we briefly describe cartilage's development and cellular and extracellular composition and organisation. We also provide an overview of collagen type II biosynthesis and purification protocols from tissues of terrestrial and marine species and recombinant systems. We then advocate the use of collagen type II as a building block in cartilage engineering approaches, based on safety, efficiency and efficacy data that have been derived over the years from numerous in vitro and in vivo studies.
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