Optimizing Organ Preservation Strategies in Localized Muscle Invasive Bladder Cancer

It is well established that a trimodality bladder preservation strategy of maximal transurethral resection of bladder tumour (TURBT) followed by radical radiotherapy with the concurrent administration of a radiosensitising agent is in clinical equipoise with radical cystectomy in the treatment of localised muscle invasive bladder cancer (MIBC).1,2 Many guidelines recommend discussing the merits of both options with a radiation oncologist as well as a urological surgeon who performs radical cystectomy with a view to enabling informed decision making by patients.