线粒体
脂滴
细胞器
内质网
脂质代谢
细胞生物学
脂肪肝
膜接触部位
生物
生物化学
膜蛋白
病理
医学
膜
疾病
整体膜蛋白
作者
Xiaowen Ma,Hui Qian,Allen Chen,Hong‐Min Ni,Wen‐Xing Ding
出处
期刊:Cells
[MDPI AG]
日期:2021-09-01
卷期号:10 (9): 2273-2273
被引量:31
标识
DOI:10.3390/cells10092273
摘要
Emerging evidence suggests that mitochondrion-endoplasmic reticulum (ER) and mitochondrion-lipid droplet (LD) contact sites are critical in regulating lipid metabolism in cells. It is well established that intracellular organelles communicate with each other continuously through membrane contact sites to maintain organelle function and cellular homeostasis. The accumulation of LDs in hepatocytes is an early indicator of non-alcoholic fatty liver disease (NAFLD) and alcohol-related liver disease (ALD), which may indicate a breakdown in proper inter-organelle communication. In this review, we discuss previous findings in mitochondrion-ER and mitochondrion-LD contact, focusing on their roles in lipid metabolism in hepatocytes. We also present evidence of a unique mitochondrion-LD contact structure in hepatocytes under various physiological and pathological conditions and propose a working hypothesis to speculate about the role of these structures in regulating the functions of mitochondria and LDs and their implications in NAFLD and ALD.
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