Fast Synthesis of Tetra-Aryl-Substituted Aza-BODIPYs

Abstract This article presents the fast and easy way to synthesize tetra-aryl-substituted aza-BODIPY dyes. The standard synthesis technique in solution was modified by mechanochemical solid-state grinding and minimizing the solvent amount. These approaches substantially reduced reaction time. Obtained dyes showed moderate fluorescence in near-infrared window in biological tissue and may be further used in areas of biological sensing.