材料科学
纳米管
涂层
盐酸盐
生物相容性
压电
同轴
药物输送
纳米技术
化学工程
复合材料
碳纳米管
有机化学
化学
冶金
工程类
电气工程
作者
Cong Wu,Xinghui Wei,Kang Zhao,Junyi Jiang,Mengzhen Jiao,Junhua Cheng,Zhen Tang,Zheng Guo,Yufei Tang
标识
DOI:10.1016/j.ceramint.2021.03.073
摘要
Nanotube coatings on titanium surfaces have favorable biocompatibility and structures and are widely used in local drug delivery. However, when a drug freely diffuses out of a nanotube, it leads to an explosive release, making the duration of action extremely short. In this study, a high concentration of vancomycin hydrochloride region similar to a dam was formed on a nanotube coating surface by exploiting the attraction of the electric charge generated by the energy conversion of the piezoelectric effect to vancomycin hydrochloride. The “dam” not only reduces the diffusion rate of vancomycin hydrochloride inside the nanotube into the dam and the diffusion rate of the dam to the outside but also forms a high concentration of vancomycin hydrochloride action region. The free diffusion rate of vancomycin hydrochloride loaded on the TiO2 @ BaTiO3 coaxial nanotubes was reduced by the piezoelectric effect, and the cumulative release of vancomycin hydrochloride for 7 days is reduced by 54.8%. The polarized vancomycin-containing coaxial nanotube coating has a long-lasting antibacterial effect on Staphylococcus aureus. The TiO2 @ BaTiO3 coaxial nanotubes loaded with vancomycin hydrochloride coating with piezoelectric properties has potential application value in controlled drug delivery.
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