Hydroxycamptothecin Stealth Liposomes: Containing TPGS as a Novel PEGylated Long-Circulating Coating Material

The goal of this study was to develop long-circulating liposomes of hydroxylcamptothecin (HCPT) with TPGS as a new coating material. Liposomes were prepared by a thin-film dispersion method with the lipids comprised phosphatidylcholine, cholesterol and TPGS. By contrast, other common PEGylated derivatives were also involved. HCPT-loaded liposomes with TPGS as coating material showed similar physicochemical characteristics and in vitro release profile to liposomes with DSPE-PEG or DPPE-PEG. It is suggested that TPGS can be applied as a novel coating material for long-circulating liposomes.