Luliconazole: a review of a new antifungal agent for the topical treatment of onychomycosis

Summary Luliconazole is a novel, broad‐spectrum, imidazole antifungal under development in the USA as a treatment for dermatophytic skin and nail infections. In vitro , luliconazole is one of the most potent antifungal agents against filamentous fungi including dermatophytes. Luliconazole has been formulated in a 10% solution with unique molecular properties, which allow it to penetrate the nail plate and rapidly achieve fungicidal levels in the nail unit. These properties make luliconazole a potent compound in the treatment of onychomycosis. This article reviews the development of luliconazole solution, 10% its molecular properties, preclinical and clinical data and its future perspectives for the treatment of fungal infections.