冷漠
心理学
眶额皮质
痴呆
卡德西尔
额叶
扣带皮质
医学
内科学
神经科学
认知
前额叶皮质
疾病
中枢神经系统
作者
Éric Jouvent,Sonia Reyes,J. F. Mangin,Pauline Roca,Marc de Perrot,Benjamin Thyreau,Dominique Hervé,Martin Dichgans,Hugues Chabriat
出处
期刊:Neurology
[Ovid Technologies (Wolters Kluwer)]
日期:2011-04-25
卷期号:76 (17): 1472-1477
被引量:42
标识
DOI:10.1212/wnl.0b013e31821810a4
摘要
Apathy is a debilitating symptom in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), the pathophysiology of which remains poorly understood. The aim of this study was to evaluate the neuroanatomic correlates of apathy, using new MRI postprocessing methods based on the identification of cortical sulci, in a large cohort of patients with CADASIL.A total of 132 patients with genetically confirmed diagnosis were included in this prospective cohort study. Global cognitive performances were assessed by the Mattis Dementia Rating Scale (MDRS) and disability by the modified Rankin score (mRS). Apathy was defined according to standard criteria. Depth, width, and cortical thickness of 10 large sulci of the frontal lobe in each hemisphere were measured. Logistic regression modeling was used to evaluate the links between apathy and cortical thickness, depth, or width of the different sulci. All models were adjusted for age, gender, level of education, MDRS, mRS, depression, and global brain volume.Complete MRI datasets of high quality were available in 119 patients. Depth of the posterior cingulate sulcus exhibited the strongest association with apathy in fully adjusted models (right: p value = 0.0006; left: p value = 0.004). Depth and width of cortical sulci in mediofrontal and orbitofrontal areas were independently associated with apathy. By contrast, cortical thickness was not.Cortical morphology in mediofrontal and orbitofrontal areas, by contrast to cortical thickness, is strongly and independently associated with apathy. These results suggest that apathy is related to a reduction of cortical surface rather than of cortical thickness secondary to lesion accumulation in CADASIL.
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