透皮
超声波传感器
声学
胰岛素释放
超声波
材料科学
医学
生物医学工程
内分泌学
物理
糖尿病
药理学
1型糖尿病
作者
Joseph Luis,Eun Joo Park,Richard J. Meyer,Nadine Smith
出处
期刊:Journal of the Acoustical Society of America
[Acoustical Society of America]
日期:2007-09-26
卷期号:122 (4): 2022-2030
被引量:33
摘要
Circular cymbal ultrasound arrays have been shown to be effective in delivering therapeutic levels of insulin in rats, rabbits, and pigs. To improve delivery efficiency, a rectangular cymbal design was desired in order to achieve a broader spatial intensity field without increasing the size of the device or the spatial-peak temporal-peak intensity (ISPTP). With a similar intensity (50mW∕cm2), the goal was to determine if the 3×1 rectangular cymbal array could perform significantly better than the 3×3 circular array for glucose reduction in hyperglycemic rabbits. Rabbit experiments were performed using three groups: nonsonicated control (n=3), ultrasound exposure using a circular cymbal array (n=3), and ultrasound exposure using a rectangular cymbal array (n=3). Rabbits were anesthetized and a water tight reservoir that held the insulin was fastened on the rabbit’s thigh. At the beginning of the experiment and every 15min for 90min, the blood glucose level was determined. For comparison between individual rabbits, the absolute level is normalized by subtracting out the baseline in order to arrive at the change in glucose level. For the control group, the normalized glucose level increased (more hyperglycemic) to +80.0±28.8mg∕dl (mean±SEM). Using the circular array, the glucose level decreased to −146.7±17.8mg∕dl at 90min. However, using the rectangular cymbal array, the glucose decreased faster and to a level of −200.8±5.9mg∕dl after 90min. These results indicated the feasibility of the rectangular cymbal array as an improved device for drug delivery.
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