肌萎缩侧索硬化
脊髓
SOD1
运动神经元
超微结构
腰脊髓
生物
腰椎
病理
细胞质包涵体
神经科学
病态的
转基因小鼠
细胞质
解剖
转基因
疾病
细胞生物学
医学
基因
生物化学
作者
Yansu Guo,Chunyan Li,Dongxia Wu,Shuyu Wu,Cheng Yang,Yaling Liu,Hongran Wu,Zhongyao Li
出处
期刊:Brain Research
[Elsevier]
日期:2010-07-19
卷期号:1353: 234-244
被引量:18
标识
DOI:10.1016/j.brainres.2010.07.025
摘要
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by selective motor neuron death. We report the characteristics of ultrastructural pathological changes of inclusions and aggregations in the neuronal axons, glial cells and ventral roots of lumbar spinal cord in SOD1-G93A transgenic mice using light and electron transmission microscope at different stages of disease. The most noteworthy is that mutant SOD1 accumulations in the cytoplasm of motor neurons precede the numerous inclusions. Inclusions manifested differently according to the specified locations. This study provided further information to the previous reports about pathological changes of ALS.
科研通智能强力驱动
Strongly Powered by AbleSci AI