Wnt信号通路
WNT3A型
肝星状细胞
干瘪的
LRP5
LRP6型
癌症研究
信号转导
细胞生物学
细胞凋亡
生物
化学
内分泌学
生物化学
作者
Sun Jung Myung,Jung Hwan Yoon,Geum Youn Gwak,Won Kim,Jeong Hoon Lee,Kang Mo Kim,Chan Soo Shin,Ja June Jang,Sung Hee Lee,Soomi Lee,Hyo Suk Lee
出处
期刊:FEBS Letters
[Wiley]
日期:2007-05-29
卷期号:581 (16): 2954-2958
被引量:77
标识
DOI:10.1016/j.febslet.2007.05.050
摘要
Wnt signaling was implicated in pulmonary and renal fibrosis. Since Wnt activity is enhanced in liver cirrhosis, Wnt signaling may also participate in hepatic fibrogenesis. Thus, we determined if Wnt signaling modulates hepatic stellate cell (HSC) activation and survival. Wnt3A treatment significantly activated human HSCs, while this was inhibited in secreted frizzled‐related protein 1 (sFRP1) overexpressing cells. Wnt3A treatment significantly suppressed TRAIL‐induced apoptosis in control HSCs versus sFRP1 over‐expressing cells. Particularly, caspase 3 was more activated in sFRP1 over‐expressing cells following TRAIL and Wnt3A treatment. These observations imply that Wnt signaling promotes hepatic fibrosis by enhancing HSC activation and survival.
科研通智能强力驱动
Strongly Powered by AbleSci AI