分子内力
环加成
选择性
化学
Diels-Alder反应
立体化学
催化作用
药物化学
有机化学
作者
Donald C. Craig,Neil J. Geach
标识
DOI:10.1016/s0957-4166(00)80016-6
摘要
The synthesis and thermally-induced intramolecular Diels-Alder (IMDA) reaction of (S)s-(+)-S-[(1E,7E)-1,7,9-decatrienyl]-S-phenyl-N-(p-tolylsulphonyl)sulphoximine 4 is described. A model is proposed for the cis-selectivity of the cycloaddition based on previous results from the reactions of sulphonyl-substituted trienes. The stereochemistry of the major cis-fused cycloadduct is determined by single-crystal X-ray analysis of that obtained from reaction of racemic 4.
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