细胞周期
DNA修复
细胞周期检查点
G2-M DNA损伤检查点
支票1
DNA损伤
细胞生物学
生物
细胞周期进展
基因组不稳定性
细胞
DNA
癌症研究
遗传学
作者
Dana Branzei,Marco Foiani
摘要
The repair of DNA lesions that occur endogenously or in response to diverse genotoxic stresses is indispensable for genome integrity. DNA lesions activate checkpoint pathways that regulate specific DNA-repair mechanisms in the different phases of the cell cycle. Checkpoint-arrested cells resume cell-cycle progression once damage has been repaired, whereas cells with unrepairable DNA lesions undergo permanent cell-cycle arrest or apoptosis. Recent studies have provided insights into the mechanisms that contribute to DNA repair in specific cell-cycle phases and have highlighted the mechanisms that ensure cell-cycle progression or arrest in normal and cancerous cells.
科研通智能强力驱动
Strongly Powered by AbleSci AI