作者
Geoffrey Hom,Robert Graham,Barmak Modrek,Kimberly E. Taylor,Ward Ortmann,Sophie Garnier,Annette T. Lee,Sharon A. Chung,Ricardo C. Ferreira,Poonam Pant,Dennis G. Ballinger,Roman Kosoy,F. Yesim Demirci,M. Ilyas Kamboh,Amy Kao,Chao Tian,Elisabet Svenungsson,Mattias Collin,Solbritt Rantapää‐Dahlqvist,Michelle Petri,Susan Manzi,Michael F. Seldin,Lars Rönnblom,Ann-Christine Syvänen,Lindsey A. Criswell,Peter K. Gregersen,Timothy W. Behrens
摘要
Systemic lupus erythematosus (SLE) is a clinically heterogeneous disease in which the risk of disease is influenced by complex genetic and environmental contributions. Alleles of HLA-DRB1, IRF5, and STAT4 are established susceptibility genes; there is strong evidence for the existence of additional risk loci.
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