生物
再生(生物学)
髓鞘
神经突
坐骨神经
轴突
雪旺细胞
细胞生物学
周围神经损伤
神经科学
脊髓
外周神经系统
神经损伤
坐骨神经损伤
解剖
中枢神经系统
体外
生物化学
作者
Caroline Pot,Marjo Simonen,Oliver Weinmann,Lisa Schnell,Franziska Christ,Sascha Stoeckle,Philipp Berger,Thomas Rülicke,Ueli Suter,Martin E. Schwab
标识
DOI:10.1083/jcb.200206068
摘要
Înjured axons in mammalian peripheral nerves often regenerate successfully over long distances, in contrast to axons in the brain and spinal cord (CNS). Neurite growth-inhibitory proteins, including the recently cloned membrane protein Nogo-A, are enriched in the CNS, in particular in myelin. Nogo-A is not detectable in peripheral nerve myelin. Using regulated transgenic expression of Nogo-A in peripheral nerve Schwann cells, we show that axonal regeneration and functional recovery are impaired after a sciatic nerve crush. Nogo-A thus overrides the growth-permissive and -promoting effects of the lesioned peripheral nerve, demonstrating its in vivo potency as an inhibitor of axonal regeneration.
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