HMGB1
愤怒(情绪)
细胞外
受体
疾病
细胞生物学
运动性
细胞
生物
细胞骨架
败血症
信号转导
免疫学
癌症研究
医学
神经科学
遗传学
内科学
作者
Heikki Rauvala,Ari Rouhiainen
出处
期刊:Current Molecular Medicine
[Bentham Science]
日期:2007-12-01
卷期号:7 (8): 725-734
被引量:105
标识
DOI:10.2174/156652407783220750
摘要
HMGB1/Amphoterin is a ubiquitous, highly conserved DNA-binding protein that can be also released to the extracellular space by various cell types. Extracellular HMGB1 regulates migratory responses of several cell types through binding to RAGE that communicates with the cytoskeleton to regulate cell motility. HMGB1- induced cell signalling has been associated with mechanisms of several diseases, including cancer, sepsis, rheumatoid arthritis, stroke and atherosclerosis. This article reviews the evidence linking the functional roles of HMGB1 to RAGE signalling. Furthermore, we discuss the molecular and cellular mechanisms that may explain the roles of HMGB1/RAGE in diverse disease processes. Keywords: RAGE-binding region, HMGB1 expression, MAPK kinases, inflammation, plasticity
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