药物输送
二硫键
纳米技术
药品
纳米颗粒
体内
抗癌药
化学
计算机科学
组合化学
材料科学
生物化学
药理学
医学
生物
生物技术
作者
Jinbing Xie,Yi Cao,Xia Mao,Xiang Gao,Meng Qin,Jiwu Wei,Wei Wang
标识
DOI:10.1002/adhm.201200285
摘要
Upon controlled UV illumination, disulfide bonds in bovine α-lactalbumin (BLA) are selectively broken, leading to self-assembly of the BLA and doxorubicin (DOX) molecules into nanoparticles via hydrophobic interactions and intermolecular disulfide bonds. Such protein–drug nanoparticles have synergistic anticancer activity in vitro and tumor-homing specificity in vivo, which are of great potential for systemic drug delivery in cancer therapy. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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