清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Regulation of Wound Healing by Growth Factors and Cytokines

伤口愈合 皮肤修复 受体 医学 内生 炎症 生物 生长因子 细胞生物学 免疫学 遗传学 内分泌学
作者
Sabine Werner,Richard Grose
出处
期刊:Physiological Reviews [American Physiological Society]
卷期号:83 (3): 835-870 被引量:3277
标识
DOI:10.1152/physrev.2003.83.3.835
摘要

Werner, Sabine, and Richard Grose. Regulation of Wound Healing by Growth Factors and Cytokines. Physiol Rev 83: 835–870, 2003; 10.1152/physrev.00032.2002.—Cutaneous wound healing is a complex process involving blood clotting, inflammation, new tissue formation, and finally tissue remodeling. It is well described at the histological level, but the genes that regulate skin repair have only partially been identified. Many experimental and clinical studies have demonstrated varied, but in most cases beneficial, effects of exogenous growth factors on the healing process. However, the roles played by endogenous growth factors have remained largely unclear. Initial approaches at addressing this question focused on the expression analysis of various growth factors, cytokines, and their receptors in different wound models, with first functional data being obtained by applying neutralizing antibodies to wounds. During the past few years, the availability of genetically modified mice has allowed elucidation of the function of various genes in the healing process, and these studies have shed light onto the role of growth factors, cytokines, and their downstream effectors in wound repair. This review summarizes the results of expression studies that have been performed in rodents, pigs, and humans to localize growth factors and their receptors in skin wounds. Most importantly, we also report on genetic studies addressing the functions of endogenous growth factors in the wound repair process.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
18秒前
刘逸然啊发布了新的文献求助10
24秒前
26秒前
小蘑菇应助宁不惜采纳,获得30
30秒前
back you up完成签到,获得积分10
39秒前
刘逸然啊完成签到,获得积分10
40秒前
草木完成签到,获得积分10
49秒前
科小白完成签到 ,获得积分10
53秒前
西红柿不吃皮完成签到 ,获得积分10
55秒前
zhangsan完成签到,获得积分10
1分钟前
火星上惜天完成签到 ,获得积分10
1分钟前
1分钟前
一夜很静完成签到,获得积分10
1分钟前
白华苍松发布了新的文献求助10
1分钟前
2分钟前
YMkaiye发布了新的文献求助10
2分钟前
2分钟前
WW发布了新的文献求助10
2分钟前
YMkaiye完成签到,获得积分10
2分钟前
2分钟前
波波完成签到 ,获得积分10
2分钟前
3分钟前
归尘发布了新的文献求助10
3分钟前
蜂蜜不是糖完成签到 ,获得积分10
3分钟前
阿尔法贝塔完成签到 ,获得积分10
4分钟前
清秀的之桃完成签到 ,获得积分10
4分钟前
5分钟前
归尘发布了新的文献求助10
5分钟前
小二郎应助Clement洋采纳,获得30
5分钟前
zjh完成签到,获得积分10
5分钟前
Clement洋完成签到,获得积分20
5分钟前
5分钟前
Clement洋发布了新的文献求助30
5分钟前
Anto发布了新的文献求助10
6分钟前
科研通AI5应助陈纸溪采纳,获得10
6分钟前
conquer完成签到,获得积分10
6分钟前
suiwuya完成签到,获得积分10
7分钟前
午后狂睡完成签到 ,获得积分10
7分钟前
Shicheng完成签到,获得积分10
7分钟前
Lucas应助文艺猫咪采纳,获得10
8分钟前
高分求助中
Continuum Thermodynamics and Material Modelling 3000
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Structural Load Modelling and Combination for Performance and Safety Evaluation 800
Conference Record, IAS Annual Meeting 1977 610
Interest Rate Modeling. Volume 3: Products and Risk Management 600
Interest Rate Modeling. Volume 2: Term Structure Models 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3555803
求助须知:如何正确求助?哪些是违规求助? 3131390
关于积分的说明 9391041
捐赠科研通 2831096
什么是DOI,文献DOI怎么找? 1556360
邀请新用户注册赠送积分活动 726516
科研通“疑难数据库(出版商)”最低求助积分说明 715866