Heterocyclization, Dyeing Applications and Anticancer Evaluations of Benzimidazole Derivatives: Novel Synthesis of Thiophene, Triazole and Pyrimidine Derivatives

NUMBER of novel hydrazono benzimidazole, thiophene, ……...triazole and pyrimidine derivatives were prepared and their dyeing properties evaluated.The newly synthesized compounds based on 1-(1H-benzimidazol-2-yl)-propan-2-one 3. The reactivity of compound 3 towards different chemical reagents was studied.The structure of the synthesized compounds was established based on elemental analysis and spectral data.Dyes were applied at 1% and 3% depth for disperse dyeing of (nylon 6 + polyester) and polyester fabrics.Their spectral characteristics and fastness properties were measured and evaluated.On the other hand, the anticancer activity of some of the newly synthesized compounds was studied and evaluated.Compounds 5a, 9b, 14b and 17c revealed higher effect when screened in vitro against some human cancer cell lines than the reference CHS 828.