唑来膦酸
医学
德诺苏马布
骨重建
氟化钠
下颌骨(节肢动物口器)
双膦酸盐
核医学
牙科
骨质疏松症
内科学
泌尿科
氟化物
骨吸收
化学
属
无机化学
生物
植物
作者
Mao Fushimi,Yumiko Ohbayashi,Fumi Nakai,Takashi Norikane,Yuka Yamamoto,Yoshihiro Nishiyama,Minoru Miyake
出处
期刊:Oral Radiology
[Springer Nature]
日期:2022-02-10
卷期号:38 (4): 594-600
被引量:4
标识
DOI:10.1007/s11282-022-00594-2
摘要
The primary purpose of this study was to determine whether both zoledronic acid (ZA) and denosumab (Dmab) equally suppress bone remodeling of the normal mandible, and the secondary purpose was to determine the influence of ZA and Dmab on other normal bones.18F-sodium fluoride-positron-emission-tomography (18F-NaF-PET) was used to perform quantitative analysis of the bone metabolism in various parts. The end points of the study were the mean standardized uptake value (SUV) of each member of the ZA group (n = 9), the Dmab group (n = 16), and the Control group (n = 23).The SUV at the thoracic vertebrae in the ZA group were significantly lower than those of the Dmab and Control group (p < 0.05) In addition, the mean SUVs of the cervical vertebrae in the ZA group were significantly lower than those in the Control group (p < 0.05). There was no significant difference among ZA, Dmab and Control group in the other sites. There was no significant difference between the Dmab and Control groups at all sites.The remodeling of mandible was not suppressed due to the treatment with anti-resorptive agents. Differences in the mechanisms of action between the BP and Dmab caused the specificity of the effect on the metabolism of normal bone.
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