吞噬作用
小胶质细胞
生物
间隙
神经科学
星形胶质细胞
中枢神经系统
人口
髓鞘
免疫学
神经胶质
细胞生物学
炎症
医学
环境卫生
泌尿科
作者
Hiroyuki Konishi,Schuichi Koizumi,Hiroshi Kiyama
出处
期刊:Glia
[Wiley]
日期:2022-02-10
卷期号:70 (6): 1009-1026
被引量:46
摘要
Abstract Elimination of dead or live cells take place in both a healthy and diseased central nervous system (CNS). Dying or dead cells are quickly cleared by phagocytosis for the maintenance of a healthy CNS or for recovery after injury. Live cells or parts thereof, such as the synapses and myelin, are appropriately eliminated by phagocytosis to maintain or refine neural networks during development and adulthood. Microglia, the specific population of resident macrophages in the CNS, are classically considered as primary phagocytes; however, astrocytes have also been highlighted as phagocytes in the last decade. Phagocytic targets and receptors are reported to be mostly common between astrocytes and microglia, which raises the question of how astrocytic phagocytosis differs from microglial phagocytosis, and how these two phagocytic systems cooperate. In this review, we address the consequences of astrocytic phagocytosis, particularly focusing on these elusive points.
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