三氟甲基化
化学
氧化剂
催化作用
亲核细胞
组合化学
串联
光催化
有机化学
材料科学
烷基
三氟甲基
复合材料
作者
Abdurrahman Türksoy,Samir Bouayad‐Gervais,Franziska Schoenebeck
标识
DOI:10.1002/chem.202201435
摘要
While the N-trifluoromethylation of cyclic ureas is of interest for the potential to fundamentally change the properties of these biologically relevant moieties, the single synthetic procedure known to date describing their access only gives 4,4-disubstituted or fused aromatic cyclic N-CF3 urea derivatives. We herein report an alternative approach to unleash access to the 4-monosubstituted imidazolidinone motif. The strategy relies on straightforward cyclization of readily accessible acyclic ureas, enabled by Ag-catalysis or light-assisted proton coupled electron transfer. The cyclic core is shown to be highly robust and amenable to various derivatizations, such as tandem Ni-catalysis, C-B, C-N, C-C cross couplings or C-H functionalizations, tolerating basic, nucleophilic and/or oxidizing conditions.
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