糖蛋白
表面改性
化学
细胞内
化学改性
生物化学
翻译后修饰
组合化学
细胞生物学
计算生物学
生物
酶
物理化学
作者
Wu Cao,Lu Zheng,Biao Dou,Xueke Zeng,Mengji Cao,Jiajia Wang,Xia Li
标识
DOI:10.1016/j.cclet.2022.06.021
摘要
A novel metabolic chemical reporter of Ac36deoGlcNAz was developed and confirmed as an effective probe for O-GlcNAc modification. Ac36deoGlcNAz labeling predominantly occurs in intracellular O-GlcNAcylated proteins rather than cell-surface glycoproteins. Of note, it could reduce the artificial S-glyco-modification compared to Ac4GalNAz and Ac4GlcNAz. This new reporter allows to be widely used in the field of proteomic identification of O-GlcNAcylation.
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