Association of Polyfluoroalkyl Substances and Allergy in US Adolescents

The aim of this study was to investigate association between polyfluoroalkyl substances (PFASs) and allergy in US adolescents.This study was conducted in the National Health and Nutrition Examination Survey 2005-2006. PFAS as a universal pollutant can be obtained directly from laboratory data files. Allergy included current allergic symptoms and allergen sensitization. The aim of the study was to investigate the association between PFAS and allergy in US adolescents.Multivariate regression models showed that PFAS was positively associated with current allergic symptoms (adjusted odds ratio, 1.01; 95% confidence interval [CI], 1-1.03). With PFAS as a categorical variable, compared with the lowest tertile, the adjusted odds ratios with increasing tertiles were 1.21 (95% CI, 0.74-1.96) and 1.67 (95% CI, 1.01-2.74).Our study shows that PFASs are associated with increased incidence of current allergic symptoms in US adolescents. More prospective studies are needed to provide evidences.