双金属片
化学
电化学
检出限
色氨酸
电化学气体传感器
选择性
线性范围
非阻塞I/O
反应性(心理学)
电导率
金属有机骨架
无机化学
电极
组合化学
金属
氨基酸
有机化学
催化作用
色谱法
物理化学
生物化学
吸附
病理
医学
替代医学
作者
Wei Huang,Yao Chen,Lingyan Wu,Mei Long,Zhifeng Lin,Qianqian Su,Fuli Zheng,Siying Wu,Huangyuan Li,Guangxia Yu
出处
期刊:Talanta
[Elsevier]
日期:2022-09-01
卷期号:247: 123596-123596
被引量:21
标识
DOI:10.1016/j.talanta.2022.123596
摘要
L-tryptophan (Trp) is an essential amino acid for humans and plays crucial roles in many metabolic functions. Trp levels can be used for diagnosing different kinds of metabolic disorders and the symptoms associated with those diseases. Herein, a novel, simple and sensitive sensor based on 3D peony-like bimetallic conductive MOFs (Co-Ni-MOFs) was fabricated for the electrochemical determination of Trp. The bimetallic conductive MOFs were synthesized by a facile one-pot hydrothermal process. On account of the synergy between the Ni2+ and Co2+ ions, the bimetallic Co-Ni-MOFs showed excellent electrochemical performance, including good conductivity, large effective surface areas, and high electrocatalytic reactivity toward the oxidation of Trp. Consequently, the Co-Ni-MOFs-modified electrodes obtained a wide linear range from 10 nmol L-1 to 300 μmol L-1 and a low detection limit of 8.7 nmol L-1 (S/N = 3) for Trp. Additionally, the prepared sensor also displayed high selectivity, long-term stability and reproducibility. Moreover, the proposed sensor was successfully applied to determine the levels of Trp in the plasma of mice after cadmium intoxication.
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