Novel insights into toxic and chronic liver disease

3High Prevalence of Ibuprofen Drug-Induced Liver Injury in Spanish and Latin-American Registries……………………………………………………83 Chapter 4Relevance of c-Jun N-terminal kinase (JNK) in Ibuprofen-induced acute liver injury……………………………………………………………………………………..99 Chapter 5Combined activities of JNK1 and JNK2 in hepatocytes protect against toxic liver injury…………………………………………………………………………123Chapter 6 Liver injury after Methylprednisolone pulses: A disputable cause of hepatotoxicity.Analysis from the Spanish Latin DILI Registry and a literature review…………………………………………………………………………………………………..161 Chapter 7Definition and risk factors for chronicity following acute idiosyncratic drug-induced liver injury………………………………………………….183 Chapter 8Learning point: Three case reports on drug-induced liver toxicity due to diverse drugs and conditions……………………………………………………………205 Part II Chronic liver disease section ChapterReversal of liver fibrosis: from fiction to reality……………………………………..233Chapter Therapeutic intervention against c-Jun N-terminal kinase-2 (Jnk2) ameliorates end-stage chronic liver disease………………………………………….263Chapter 11 Disruption of the FasL/Fas axis protects against inflammation-derived tumorigenesis in chronic liver disease……………………………………………………293 Part III Conclusion sectionChapter General Discussion…………………….………………………………………………………...