谷氨酸羧肽酶Ⅱ
前列腺癌
癌症
前列腺
抗原
化学
膜生物学
癌症研究
医学
计算生物学
药理学
生物化学
生物
内科学
免疫学
膜
作者
Zahra Nikfarjam,Farshid Zargari,Alireza Nowroozi,Omid Bavi
出处
期刊:Biophysical Reviews
[Springer International Publishing]
日期:2022-01-13
卷期号:14 (1): 303-315
被引量:5
标识
DOI:10.1007/s12551-021-00919-1
摘要
Prostate-specific membrane antigen (PSMA), also called glutamate carboxypeptidase II (GCP(II)), is a Zn-dependent metalloprotease that is known as a well prostate cancer indication and a potential targeting towards anti-cancer medicines and drug delivery. Because of its centrality in the diagnostics and treatment of prostate cancer, several types of inhibitors are designed with particular scaffolds. In this study, important groups of related inhibitors as well as reported experimental and computational studies are being reviewed, in which we examined three functional groups on each group of structures. The importance of computational biochemistry and the necessity of extensive research in this area on PSMA and its effective ligands are recommended.
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