秀丽隐杆线虫
肉桂酸
神经保护
氧化应激
毒性
胆碱能的
淀粉样前体蛋白
蛋白质稳态
乙酰胆碱酯酶
淀粉样蛋白(真菌学)
神经退行性变
神经毒性
胆碱能神经元
线粒体
化学
细胞生物学
神经科学
阿尔茨海默病
药理学
生物
生物化学
抗氧化剂
内科学
医学
基因
疾病
酶
有机化学
植物
作者
Yun Chen,Yarong Wang,Qiao Qin,Yali Zhang,Lingling Xie,Jie Xiao,Yong Cao,Zuanxian Su,Yunjiao Chen
出处
期刊:Food & Function
[The Royal Society of Chemistry]
日期:2022-01-01
卷期号:13 (8): 4624-4640
被引量:16
摘要
Amyloid-β peptide (Aβ)-induced cholinergic system and mitochondrial dysfunction are major risk factors for Alzheimer's disease (AD). Our previous studies found that carnosic acid (CA), an important polyphenol antioxidant, could significantly delay Aβ1-42-mediated acute paralysis. However, many details and underlying mechanisms of CA's neuroprotection against Aβ-induced cholinergic system defects and mitochondrial dysfunction remain unclear. Herein, we deeply investigated the effects and the possible mechanisms of CA-mediated protection against Aβ toxicity in vivo through several AD Caenorhabditis elegans strains. The results showed CA delayed age-related paralysis and Aβ deposition, and significantly protected neurons from Aβ-induced toxicity. CA might downgrade the expression of ace-1 and ace-2 genes, and upregulate cha-1 and unc-17 genes to inhibit acetylcholinesterase activity and relieve Aβ-caused cholinergic system defects. Furthermore, CA might also ameliorate Aβ-induced mitochondrial imbalance and oxidative stress through up-regulating the expression of phb-1, phb-2, eat-3, and drp-1 genes. The enhancements of the cholinergic system and mitochondrial function might be the reasons for the amelioration of Aβ-mediated toxicity and Aβ aggregation mediated by CA. These findings have helped us to understand the CA anti-Aβ activity in C. elegans and the potential mechanism of action.
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