多细胞生物
生物
类有机物
诱导多能干细胞
组织工程
发育生物学
过程(计算)
合成生物学
多学科方法
显微解剖学
神经科学
计算生物学
细胞生物学
计算机科学
胚胎干细胞
解剖
遗传学
细胞
基因
操作系统
社会学
社会科学
作者
Ibrahim Zarkesh,Mohammad Kazemi Ashtiani,Zahra Shiri,Saeideh Aran,Thomas Braun,Hossein Baharvand
标识
DOI:10.1016/j.stemcr.2022.02.004
摘要
Multicellular organisms of various complexities self-organize in nature. Organoids are in vitro 3D structures that display important aspects of the anatomy and physiology of their in vivo counterparts and that develop from pluripotent or tissue-specific stem cells through a self-organization process. In this review, we describe the multidisciplinary concept of “synthetic developmental biology” where engineering approaches are employed to guide multicellular organization in an experimental setting. We introduce a novel classification of engineering approaches based on the extent of microenvironmental manipulation applied to organoids. In the final section, we discuss how engineering tools might help overcome current limitations in organoid construction.
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