Satellite networking, as the future development direction of aero-space, requires high-precision autonomous fault diagnosis capability for a single satellite. In this paper, aiming at the characteristics of closed-loop fault propagation and high data dimensionality of spacecraft control system, neural network algorithms are conducted to study the fault diagnosis of spacecraft high-dimensional coupled data. Based on the ground test data of a certain spacecraft, this paper converts the high-dimensional sequence data into grayscale images, and then uses Convolutional Neural Network (CNN) and Long Short-Term Memory (LSTM) to diagnose them respectively. The effectiveness of the methods in this paper is illustrated by comparing and validating them with three non-image-based machine learning algorithms, namely, K-NearestNeighbor, Bayesian classifier, and K-NearestNeighbor based on Principal Component Analysis.