mTORC1型
生物
酪氨酸
ATF4
氨基酸
调节器
转录因子
适应(眼睛)
细胞生物学
生物化学
营养感应
信号转导
PI3K/AKT/mTOR通路
基因
神经科学
作者
Hina Kosakamoto,Naoki Okamoto,Hide Aikawa,Yuki Sugiura,Makoto Suematsu,Ryusuke Niwa,Masayuki Miura,Fumiaki Obata
标识
DOI:10.1038/s42255-022-00608-7
摘要
The intake of dietary protein regulates growth, metabolism, fecundity and lifespan across various species, which makes amino acid (AA)-sensing vital for adaptation to the nutritional environment. The general control nonderepressible 2 (GCN2)-activating transcription factor 4 (ATF4) pathway and the mechanistic target of rapamycin complex 1 (mTORC1) pathway are involved in AA-sensing. However, it is not fully understood which AAs regulate these two pathways in living animals and how they coordinate responses to protein restriction. Here we show in Drosophila that the non-essential AA tyrosine (Tyr) is a nutritional cue in the fat body necessary and sufficient for promoting adaptive responses to a low-protein diet, which entails reduction of protein synthesis and mTORC1 activity and increased food intake. This adaptation is regulated by dietary Tyr through GCN2-independent induction of ATF4 target genes in the fat body. This study identifies the Tyr–ATF4 axis as a regulator of the physiological response to a low-protein diet and sheds light on the essential function of a non-essential nutrient.
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