孟德尔随机化
观察研究
多发性硬化
医学
随机对照试验
疾病
心理学
精神科
生物
病理
遗传学
基因
基因型
遗传变异
作者
Marijne Vandebergh,Nicolas Degryse,Bénédicte Dubois,An Goris
标识
DOI:10.1007/s00415-022-11072-4
摘要
Multiple sclerosis (MS) is a complex disease with both genetic variants and environmental factors involved in disease susceptibility. The main environmental risk factors associated with MS in observational studies include obesity, vitamin D deficiency, Epstein-Barr virus infection and smoking. As modifying these environmental and lifestyle factors may enable prevention, it is important to pinpoint causal links between these factors and MS. Leveraging genetics through the Mendelian randomization (MR) paradigm is an elegant way to inform prevention strategies in MS. In this review, we summarize MR studies regarding the impact of environmental factors on MS susceptibility, thereby paying attention to quality criteria which will aid readers in interpreting any MR studies. We draw parallels and differences with observational studies and randomized controlled trials and look forward to the challenges that such work presents going forward.
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