Body Compositions Correlate With Overt Hepatic Encephalopathy after Transjugular Intrahepatic Portosystemic Shunt

医学 阿卡克信息准则 肝性脑病 肌萎缩 逐步回归 经颈静脉肝内门体分流术 内科学 逻辑回归 门体分流术 脂肪组织 生物电阻抗分析 皮下脂肪组织 体质指数 门脉高压 统计 肝硬化 数学
作者
Wenfeng Shi,Weiguo Xu,Ningning Fan,Yong Li,Xiaoqiong Chen,Yujie Zhao,Xiao Bai,Yang Yang
出处
期刊:Journal of Clinical Gastroenterology [Ovid Technologies (Wolters Kluwer)]
标识
DOI:10.1097/mcg.0000000000002014
摘要

Background: The relationship between body composition and the risk of overt hepatic encephalopathy (OHE) following transjugular intrahepatic portosystemic shunt (TIPS) needs to be investigated. Methods: Overall, 571 patients from 5 medical centers were included. To assess body compositions, we evaluated skeletal muscle indices, adipose tissue indices, sarcopenia, and myosteatosis at the third lumbar vertebral level. Univariate and Multivariate logistic regression analyses were performed to identify independent risk factors for post-TIPS OHE. An integrated score was then constructed using stepwise multiple regression analyses, with a cut-off value selected using the best Youden index. Finally, the Akaike information criterion (AIC) was performed to compare the integrated score and independent risk factors on their ability in predicting post-TIPS OHE. Results: Sarcopenia and all skeletal muscle indices had limited associations with post-TIPS OHE. The index of the subcutaneous adipose tissue (SATI) ( P =0.005; OR: 1.034, 95% CI: 1.010–1.058) and myosteatosis (297 cases, 52.01%, 125 with OHE, 42.09%; P =0.003; OR: 1.973; 95% CI: 1.262–3.084) were both ascertained as independent risk factors for post-TIPS OHE. The integrated score (Score ALL =1.5760 + 0.0107 * SATI + 0.8579 * myosteatosis) was established with a cutoff value of −0.935. The akaike information criterion (AIC) of Score ALL , SATI, and myosteatosis was 655.28, 691.18, and 686.60, respectively. Conclusions: SATI and myosteatosis are independent risk factors for post-TIPS OHE. However, the integrated score was more significantly associated with post-TIPS OHE than other skeletal muscle and adipose tissue factors.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
思源应助沙绮晴采纳,获得10
1秒前
1秒前
1秒前
xinyuxxx发布了新的文献求助10
3秒前
4秒前
5秒前
星辰大海应助magneto采纳,获得10
5秒前
5秒前
Zn应助飞云采纳,获得10
5秒前
5秒前
金新皓发布了新的文献求助10
6秒前
6秒前
lx发布了新的文献求助10
6秒前
6秒前
kryie发布了新的文献求助10
6秒前
7秒前
風声鶴唳完成签到,获得积分10
7秒前
薇薇早睡早起完成签到 ,获得积分10
8秒前
8秒前
天晴完成签到,获得积分10
9秒前
杏仁发布了新的文献求助10
10秒前
感动水杯发布了新的文献求助10
10秒前
宓之云发布了新的文献求助10
10秒前
Gray发布了新的文献求助10
11秒前
11秒前
大力的映梦完成签到,获得积分10
11秒前
感性的大楚完成签到 ,获得积分10
11秒前
Akim应助徐丹采纳,获得10
11秒前
marco完成签到 ,获得积分10
11秒前
崔棍er发布了新的文献求助10
12秒前
12秒前
双丁宝贝应助科研通管家采纳,获得10
12秒前
科研通AI5应助科研通管家采纳,获得10
12秒前
顾矜应助科研通管家采纳,获得10
12秒前
香蕉觅云应助科研通管家采纳,获得10
12秒前
Owen应助科研通管家采纳,获得10
12秒前
12秒前
13秒前
13秒前
Peckhin完成签到 ,获得积分10
13秒前
高分求助中
Production Logging: Theoretical and Interpretive Elements 2700
Mechanistic Modeling of Gas-Liquid Two-Phase Flow in Pipes 2500
Kelsen’s Legacy: Legal Normativity, International Law and Democracy 1000
Handbook on Inequality and Social Capital 800
Conference Record, IAS Annual Meeting 1977 610
Interest Rate Modeling. Volume 3: Products and Risk Management 600
Interest Rate Modeling. Volume 2: Term Structure Models 600
热门求助领域 (近24小时)
化学 材料科学 生物 医学 工程类 有机化学 生物化学 物理 纳米技术 计算机科学 内科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 量子力学 光电子学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3546689
求助须知:如何正确求助?哪些是违规求助? 3123769
关于积分的说明 9356697
捐赠科研通 2822394
什么是DOI,文献DOI怎么找? 1551413
邀请新用户注册赠送积分活动 723398
科研通“疑难数据库(出版商)”最低求助积分说明 713736