蜂毒肽
生长抑素受体
体内
生长抑素
受体
化学
神经肽
血脑屏障
内科学
生物
生物物理学
内分泌学
肽
生物化学
医学
中枢神经系统
生物技术
作者
Ida Vang Andersen,Natasha Bidesi,Vladimir Shalgunov,Jesper Tranekjær Jørgensen,Tobias Gustavsson,Kristian Strømgaard,Andreas I. Jensen,Andreas Kjær,Matthias M. Herth
标识
DOI:10.1016/j.nucmedbio.2024.108905
摘要
DOTATATE is a somatostatin peptide analog used in the clinic to detect somatostatin receptors which are highly expressed on neuroendocrine tumors. Somatostatin receptors are found naturally in the intestines, pancreas, lungs, and brain (mainly cortex). In vivo measurement of the somatostatin receptors in the cortex has been challenging because available tracers cannot cross the blood-brain barrier (BBB) due to their intrinsic polarity. A peptide called melittin, a main component of honeybee venom, has been shown to disrupt plasma membranes and increase the permeability of biological membranes. In this study, we assessed the feasibility of using melittin to facilitate the passage of [
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