医学
孟德尔随机化
认知
疾病
观察研究
全基因组关联研究
痴呆
遗传关联
单核苷酸多态性
认知功能衰退
多效性
精神科
遗传学
内科学
遗传变异
基因型
生物
基因
表型
作者
Jiao Wang,Yingyue Huang,Chunhua Bei,Huiling Yang,Zihong Lin,Lin Xu
标识
DOI:10.1136/jech-2023-221184
摘要
Circulating antioxidants are associated with a lower risk of Alzheimer's disease (AD) in observational studies, suggesting potential target areas for intervention. However, whether the associations are causal remains unclear. Here, we studied the causality between antioxidants and AD or cognitive function using two-sample Mendelian randomisation (MR).
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