Enoxaparin thromboprophylaxis in hospitalized obese pediatric patients

医学 儿科 重症监护医学
作者
Juwon Yim,Afrin Jahan,Nikolay P. Braykov,Niamh Murphy,Gary M. Woods
出处
期刊:Pediatric Blood & Cancer [Wiley]
标识
DOI:10.1002/pbc.30942
摘要

Abstract Background Enoxaparin is an anticoagulant used for pharmacologic thromboprophylaxis in pediatrics. Enoxaparin pharmacokinetics can be altered in the setting of obesity. Optimal enoxaparin dosing for thromboprophylaxis in children with obesity remains unclear. Procedure A retrospective review was conducted of pediatric patients who weighed ≥60 kg with BMI ≥ 95th percentile, received enoxaparin for thromboprophylaxis, and had at least one appropriately drawn anti‐factor Xa (anti‐Xa) from 2013 to 2022. Anti‐Xa levels were reviewed for patients initially treated with enoxaparin 30 mg every 12 h. The average daily enoxaparin dose required to achieve an anti‐Xa of 0.2–0.4 unit/mL, which was stratified by BMI percentile and weight, was calculated. Results Of 116 patients (median age 15.8 years) included for analysis, 106 patients were initially treated with enoxaparin 30 mg every 12 h. Anti‐Xa levels were <0.2 unit/mL in 53% of patients with BMI > 99th percentile and 54% of patients >100 kg. Ninety‐one patients had at least one anti‐Xa 0.2–0.4 unit/mL with an average daily enoxaparin dosing of 66 mg. When stratified by severity of obesity, higher doses were required to attain an anti‐Xa 0.2–0.4 unit/mL in patients with BMI > 99th percentile compared with those with 95th–99th percentile (67.8 ± 15.7 vs. 62 ± 5.6 mg/day, p = .01). Patients > 100 kg required significantly higher dose than those ≤100 kg (69.1 ± 15.5 vs 61.2 ± 7.3 mg/day, p = .002). Conclusions Increased initial dosing and/or anti‐Xa level monitoring should be considered in adolescents with severe obesity receiving enoxaparin thromboprophylaxis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
失眠的霸完成签到,获得积分10
2秒前
ChatGPT发布了新的文献求助10
3秒前
5秒前
多发论文完成签到,获得积分20
6秒前
6秒前
7秒前
su发布了新的文献求助10
7秒前
Xw关闭了Xw文献求助
7秒前
大个应助fjm采纳,获得10
10秒前
而为发布了新的文献求助30
10秒前
机智思真发布了新的文献求助10
10秒前
木樨316完成签到,获得积分10
10秒前
13秒前
花花完成签到 ,获得积分10
15秒前
沉默的小天鹅应助耀阳采纳,获得10
15秒前
lilila666完成签到,获得积分10
15秒前
17秒前
18秒前
18秒前
lilila666发布了新的文献求助10
20秒前
艺术家脾气完成签到,获得积分10
20秒前
丘比特应助qqq采纳,获得10
22秒前
24秒前
crazy发布了新的文献求助10
25秒前
Wayne72完成签到,获得积分0
30秒前
阿飞发布了新的文献求助10
30秒前
Zoki完成签到,获得积分10
31秒前
mini发布了新的文献求助10
32秒前
33秒前
烟雨完成签到,获得积分10
35秒前
彭栋应助文献采纳,获得30
35秒前
祖国小红花完成签到,获得积分20
35秒前
fighting完成签到 ,获得积分10
36秒前
来我家喝桂花茶完成签到,获得积分10
41秒前
41秒前
852应助一方通行采纳,获得10
41秒前
42秒前
42秒前
量子星尘发布了新的文献求助10
43秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989378
求助须知:如何正确求助?哪些是违规求助? 3531442
关于积分的说明 11254002
捐赠科研通 3270126
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809173