亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Enoxaparin thromboprophylaxis in hospitalized obese pediatric patients

医学 儿科 重症监护医学
作者
Juwon Yim,Afrin Jahan,Nikolay P. Braykov,Niamh Murphy,Gary M. Woods
出处
期刊:Pediatric Blood & Cancer [Wiley]
标识
DOI:10.1002/pbc.30942
摘要

Abstract Background Enoxaparin is an anticoagulant used for pharmacologic thromboprophylaxis in pediatrics. Enoxaparin pharmacokinetics can be altered in the setting of obesity. Optimal enoxaparin dosing for thromboprophylaxis in children with obesity remains unclear. Procedure A retrospective review was conducted of pediatric patients who weighed ≥60 kg with BMI ≥ 95th percentile, received enoxaparin for thromboprophylaxis, and had at least one appropriately drawn anti‐factor Xa (anti‐Xa) from 2013 to 2022. Anti‐Xa levels were reviewed for patients initially treated with enoxaparin 30 mg every 12 h. The average daily enoxaparin dose required to achieve an anti‐Xa of 0.2–0.4 unit/mL, which was stratified by BMI percentile and weight, was calculated. Results Of 116 patients (median age 15.8 years) included for analysis, 106 patients were initially treated with enoxaparin 30 mg every 12 h. Anti‐Xa levels were <0.2 unit/mL in 53% of patients with BMI > 99th percentile and 54% of patients >100 kg. Ninety‐one patients had at least one anti‐Xa 0.2–0.4 unit/mL with an average daily enoxaparin dosing of 66 mg. When stratified by severity of obesity, higher doses were required to attain an anti‐Xa 0.2–0.4 unit/mL in patients with BMI > 99th percentile compared with those with 95th–99th percentile (67.8 ± 15.7 vs. 62 ± 5.6 mg/day, p = .01). Patients > 100 kg required significantly higher dose than those ≤100 kg (69.1 ± 15.5 vs 61.2 ± 7.3 mg/day, p = .002). Conclusions Increased initial dosing and/or anti‐Xa level monitoring should be considered in adolescents with severe obesity receiving enoxaparin thromboprophylaxis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
FashionBoy应助andrele采纳,获得10
3秒前
27秒前
自然芷文发布了新的文献求助10
33秒前
47秒前
我是老大应助自然芷文采纳,获得10
1分钟前
iNk应助吗喽采纳,获得20
1分钟前
研友_VZG7GZ应助科研通管家采纳,获得10
1分钟前
打打应助科研通管家采纳,获得10
1分钟前
Charlie完成签到 ,获得积分10
1分钟前
CodeCraft应助Benhnhk21采纳,获得30
1分钟前
2分钟前
Benhnhk21发布了新的文献求助30
2分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
村口的帅老头完成签到 ,获得积分0
4分钟前
4分钟前
gincle完成签到 ,获得积分10
4分钟前
4分钟前
andrele发布了新的文献求助10
4分钟前
4分钟前
4分钟前
积极的台灯完成签到,获得积分10
5分钟前
紫荆完成签到,获得积分10
5分钟前
Johnson完成签到 ,获得积分10
5分钟前
李健应助科研通管家采纳,获得10
5分钟前
Benhnhk21发布了新的文献求助10
5分钟前
wanci应助淡然绝山采纳,获得10
5分钟前
6分钟前
wkjfh应助YaoQi采纳,获得10
6分钟前
dyuguo3完成签到 ,获得积分10
7分钟前
某某某发布了新的文献求助10
7分钟前
7分钟前
淡然绝山发布了新的文献求助10
7分钟前
Benhnhk21完成签到,获得积分10
7分钟前
JamesPei应助andrele采纳,获得10
7分钟前
完美世界应助xiongdi521采纳,获得10
8分钟前
8分钟前
8分钟前
xiongdi521发布了新的文献求助10
8分钟前
8分钟前
xiao涂完成签到,获得积分10
8分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990171
求助须知:如何正确求助?哪些是违规求助? 3532136
关于积分的说明 11256472
捐赠科研通 3271042
什么是DOI,文献DOI怎么找? 1805171
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234