运行x2
牙周炎
发病机制
表达式(计算机科学)
医学
牙科
基因表达
免疫学
生物
计算机科学
基因
遗传学
程序设计语言
作者
Miaomiao Wang,Chunjiao Xu,Xiaoshan Wu,Xiufang He,Yi-Ting Guo,Wenrui Zhang,Yumei Sun
出处
期刊:Oral Diseases
[Wiley]
日期:2023-04-07
卷期号:30 (3): 1525-1532
被引量:3
摘要
Abstract Objective Runt‐related transcription factor 2 (Runx2) plays an important role in bone metabolism; however, the relationship between Runx2 and periodontitis remains unclear. We investigated Runx2 expression in the gingiva of patients to explore its role in periodontitis. Methods Gingival samples of patients were collected, including healthy samples (control group) and periodontitis samples (P group). Periodontitis samples were divided into three groups based on the periodontitis stage. Samples with stage I and grade B periodontitis were in the P1 group, stage II and grade B in the P2 group, and stage III or IV and grade B in the P3 group. Immunohistochemistry and western blotting were performed to detect Runx2 levels. The probing (PD) and clinical attachment loss (CAL) were recorded. Results Runx2 expression levels in the P and P3 groups were higher than those in the control group. In addition, Runx2 expression was positively correlated with CAL and PD (r1 = 0.435, r2 = 0.396). Conclusion The high expression level of Runx2 in the gingiva of patients with periodontitis may be correlated with the pathogenesis of periodontitis.
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