NAD+激酶
CD38
生物
生殖力
卵巢储备
卵泡
卵泡期
内分泌学
内科学
卵巢
免疫系统
男科
细胞生物学
酶
免疫学
怀孕
遗传学
生物化学
医学
干细胞
不育
环境卫生
川地34
人口
作者
Rosalba Perrone,Prasanna Vadhana Ashok Kumaar,Lauren Haky,Cosmo Hahn,Rebeccah Riley,Julia L. Balough,Giuliana Zaza,Bikem Soygur,Kaitlyn Hung,Leandro Prado,Herbert G. Kasler,Ritesh Tiwari,Hiroyuki Matsui,Genesis Vega Hormazabal,Francesca E. Duncan,Eric Verdin
标识
DOI:10.1101/2023.05.08.539779
摘要
Summary Mammalian female reproductive lifespan is typically significantly shorter than life expectancy and is associated with a decrease in ovarian NAD+ levels. However, the mechanisms underlying this loss of ovarian NAD+ are unclear. Here, we show that CD38, a NAD+ consuming enzyme, is expressed in the ovarian extrafollicular space, primarily in immune cells, and its levels increase with reproductive age. Reproductively young mice lacking CD38 exhibit larger primordial follicle pools, elevated ovarian NAD+ levels, and increased fecundity relative to wild type controls. This larger ovarian reserve results from a prolonged window of follicle formation during early development. However, the beneficial effect of CD38 loss on reproductive function is not maintained at advanced age. Our results demonstrate a novel role of CD38 in regulating ovarian NAD+ metabolism and establishing the ovarian reserve, a critical process that dictates a female’s reproductive lifespan.
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