离子通道
跨膜蛋白
光门控离子通道
生物物理学
跨膜通道
离子
化学
膜
神经科学
折叠(DSP实现)
配体门控离子通道
离子运输机
电压门控离子通道
细胞生物学
生物
生物化学
受体
电气工程
工程类
有机化学
作者
William N. Green,Neil S. Millar
标识
DOI:10.1016/0166-2236(95)80009-q
摘要
Transmembrane ion channels regulate the movement of ions (particularly Na+, K+, Ca2+ and Cl−) across cellular membranes, and are critical to numerous aspects of neurobiology. Cells express a diverse array of ion-channel proteins that vary widely in their ion selectivity and in their modulation by ligands (such as neurotransmitters) or by membrane voltage. Most ion channels are multisubunit proteins and, as such, undergo an intricate series of post-translational folding, modification and oligomerization events to achieve their correct functional quaternary structure. The means by which the cell is able to accomplish this complex process of ion-channel assembly is a topic that is just beginning to be addressed experimentally.
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