Instrumentation for histotripsy ultrasound therapy: Evolution toward the clinic

传感器 治疗性超声 仪表(计算机编程) 相控阵 声学 带宽(计算) 计算机科学 超声波 物理 电信 天线(收音机) 操作系统
作者
Timothy L. Hall,Jonathan R. Sukovich,J. Cannata,J. Brian Fowlkes,Zhen Xu
出处
期刊:Journal of the Acoustical Society of America [Acoustical Society of America]
卷期号:153 (3_supplement): A138-A138
标识
DOI:10.1121/10.0018425
摘要

Histotripsy is a method of ultrasound therapy using very intense, focused sound fields to fragment tissue causing controlled and localized necrosis principally through mechanical actions of cavitation. Highly specialized instrumentation (transducers and electrical drivers) is required to produce these extreme sound fields for research into cavitation physics and therapeutic applications of histotripsy. This paper will describe the evolution of histotripsy instrumentation from the first devices up to the latest phased-array systems with hundreds of channels and transmit-receive capability. While early histotripsy systems used tone bursts generators with limited bandwidth (called “class-D” circuits) for transducer excitation, more recent ones are based on a switched inductor principle to produce shorter duration acoustic emissions. This method has been tested for peak excitation voltages up to 5 kV and 40 A in compact modular systems suitable for phased-arrays. Receive of acoustic signals by the therapeutic array for aberration correction and cavitation mapping is achieved by sensing current generated by the transducer greatly simplifying transmit-receive circuitry while maintaining very large dynamic range. A novel distributed architecture was developed for data handling and signal processing using off-the-shelf FPGA evaluation modules interfaced by ethernet. These latest features will be key to successful clinical translation and widespread adoption of histotripsy.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
皮代谷完成签到,获得积分10
刚刚
2秒前
littleblack发布了新的文献求助10
6秒前
janejane发布了新的文献求助10
7秒前
爆米花应助may采纳,获得10
8秒前
8秒前
9秒前
星辰发布了新的文献求助10
13秒前
14秒前
大胆盼烟完成签到,获得积分20
15秒前
Orange应助lumos采纳,获得10
17秒前
18秒前
cc完成签到,获得积分10
19秒前
大模型应助小二郎采纳,获得10
19秒前
森归湖遇鹿完成签到,获得积分20
19秒前
19秒前
怡心亭发布了新的文献求助20
20秒前
我是老大应助鱼鳞飞飞采纳,获得10
22秒前
酷酷的金豆儿应助liaofr采纳,获得10
22秒前
领导范儿应助维嘉采纳,获得10
22秒前
heheha发布了新的文献求助10
24秒前
25秒前
26秒前
gby2018关注了科研通微信公众号
27秒前
27秒前
大模型应助樊书南采纳,获得10
28秒前
隐形曼青应助虚心的问丝采纳,获得10
29秒前
29秒前
30秒前
31秒前
chuan完成签到,获得积分10
32秒前
KoitoYuu发布了新的文献求助10
32秒前
22yh应助葛顺采纳,获得10
33秒前
33秒前
852应助看不懂采纳,获得10
34秒前
彭于晏应助朴素易梦采纳,获得30
35秒前
35秒前
lqh0211完成签到,获得积分10
35秒前
Francis_应助自觉的乌龟采纳,获得10
36秒前
36秒前
高分求助中
The ACS Guide to Scholarly Communication 2500
Sustainability in Tides Chemistry 2000
Pharmacogenomics: Applications to Patient Care, Third Edition 1000
Studien zur Ideengeschichte der Gesetzgebung 1000
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Threaded Harmony: A Sustainable Approach to Fashion 810
《粉体与多孔固体材料的吸附原理、方法及应用》(需要中文翻译版,化学工业出版社,陈建,周力,王奋英等译) 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3084785
求助须知:如何正确求助?哪些是违规求助? 2737877
关于积分的说明 7547149
捐赠科研通 2387454
什么是DOI,文献DOI怎么找? 1265984
科研通“疑难数据库(出版商)”最低求助积分说明 613207
版权声明 598429