生物
脂肪组织
白色脂肪组织
转录组
脂肪细胞
祖细胞
白色(突变)
细胞生物学
干细胞
遗传学
基因表达
基因
内分泌学
作者
Margo P. Emont,Evan D. Rosen
标识
DOI:10.1016/j.gde.2023.102045
摘要
Adipose tissue is a heterogeneous organ, comprising cell types, including mature adipocytes, progenitor cells, immune cells, and vascular cells. Here, we discuss the heterogeneity of human and mouse white adipose tissue in general and white adipocytes specifically, focusing on how our understanding of adipocyte subpopulations has expanded with the advent of single nuclear RNA sequencing and spatial transcriptomics. Furthermore, we discuss critical remaining questions regarding how these distinct populations arise, how their functions differ from one another, and which potentially contribute to metabolic pathophysiology.
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